We found 10 articles evaluating antipsychotic medications and 15 articles evaluating benzodiazepines.
We then used these articles in a meta-analysis with a random-effects model to quantify the absolute risk reduction observed in these experiments. We conducted a systematic review to identify English language articles describing experiments that compared a benzodiazepine or antipsychotic medication to placebo for the prevention of acute cocaine toxicity in an animal model. The objective of this study was to quantify the reported efficacy of benzodiazepines and antipsychotic medication for the prevention of mortality due to cocaine poisoning. The only available controlled data are from animal models and these studies have reported inconsistent benefits.
There are no controlled human studies to determine the efficacy of benzodiazepines or antipsychotic medications for prevention or treatment of acute cocaine toxicity.
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